Dr. Chen’s laboratory focuses on computational epigenetics. Specifically they are focused on: (1) combining bioinformatics innovations with new sequencing technologies to make novel observations or to answer new biological questions; (2) understanding gene regulation networks that determine cell identity and tissue specificity in development; (3) discovering driver genes of cancer, genetic disease, or other important phenotypes. The overall goal of his research is to develop machine learning algorithms to combine epigenetic and genetic data for disease gene discovery, and to reveal the functional mechanisms underlying each discovery using molecular, cellular, and animal models.”

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